Mario Fernandez Castano was a member of the Spanish Police and one of the two officers which were assigned to act as a guide and support for
Leon S. Kennedy's mission to rescue '
Baby Eagle', otherwise known as
Ashley Graham, the kidnapped daughter of the President of the United States.
At some point they left their vehicle and went on ahead of
Leon, perhaps to gather information from the locals. Unfortunately, he and his colleague found themselves caught in the middle of a cult known as the
Los Illuminados, who worshipped a parasite known as a
Plaga (they referred to it as Las Plagas).
Mario was unfortunately captured by a hunter, brought into the basement of his lodge and then brutally murdered. It appears that he was strangled and then had his throat slit where he bled out in agony.
Leon eventually finds his ID tag in the lodge and subsequently finds his dead corpse in a different room. On his body was a walkie-talkie which
Leon picked up and attempted to call out to the other officer.
It is assumed that Mario's body is later taken from the lodge and then given to the aquatic monster
Del Lago as a meal later in the game.
While
Leon did get a response, this was short lived as the other officer was quickly found out (perhaps due to the radio noise) then around 5-10 minutes after this, taken to the town square where he was brutally burned alive at the stake.
In the original
Resident Evil 4, there are two Spanish cops (
Beard Cop and
Glasses Cop respectively) which accompany
Leon in the opening scenes. Mario is likely an updated version of
Beard Cop (but in this game, he only has a moustache).