The Pale Head is the result of an mutagenic process which
t-Virus Zombies that are infected with the Epsilon strain go through after an uncertain amount of time - similar to the way that
Crimson Head infected go through the V-ACT phase. Unfortunately not a great deal is known about the Pale Head as official research was cut short due to the destruction of the NEST-2 facility - although it is known that the experimentation into the creatures yielded extremely unreliable results and as such they were routinely destroyed.
They are essentially normal Zombies which have evolved to become more aerodynamic and have much greater regenerative properties. It's likely that their connective tissues have become much stronger also as it is impossible to dismember a Pale Head unlike a regular
Zombie which can be relatively easily. A similar creature named a Naked
Zombie were present in the Arklay Laboratory and the original NEST facility in Raccoon City.
Their skin is pale (hence the name) and withered, they are completely hairless and most of not all fat on the body is gone. Their eyes have also been covered with skin, most likely owing to the fact that the eyes are one of the first parts of the body to become completely necrotic when the
t-Virus first takes hold.
Pale Heads are also weak against Acid ammunition as the substance halts their regenerative process. These rounds were specifically engineered the combat the creature for rapid destruction.